#Ehlers–Danlos syndrome (EDS) is an inherited connective tissue dysfunction with completely different shows which were categorised into a number of major varieties. EDS is brought on by a defect within the construction, manufacturing, or processing of collagen or proteins that work together with collagen, resembling mutations within the COL5A or COL3A genes. *Collagen is a vital contributor to the bodily power of pores and skin, joints, muscle tissue, ligaments, blood vessels and visceral organs; irregular collagen renders these constructions extra elastic. In some instances, the severity of the mutation could be life-threatening. *Individuals with from EDS are sometimes misdiagnosed with hypochondriasis, despair, persistent fatigue syndrome, and different situations. **estimated to happen in about 1 in 5,000 births worldwide. Initially, prevalence estimates ranged from 1 in 250,000 to 1 in 500,000 individuals. *There isn’t any remedy for Ehlers Danlos Syndrome. Therapy is palliative.